CGC Bibliography Paper 3071

The dance of the Hox genes - Patterning the anteroposterior body axis of Caenorhabditis elegans.

Kenyon CJ, Austin J, Costa M, Cowing DW, Harris JM, Honigberg L, Hunter CP, Maloof JN, Muller-Immergluck MM, Salser SJ, Waring DA, Wang BB, Wrischnik LA

Medline:

98260725

Citation:

Cold Spring Harbor Symposia on Quantitative Biology 62: 293-305 1998

Type:

REVIEW

Genes:

ceh-13 egl-5 lin-1 lin-22 lin-39 mab-5 pal-1

Abstract:

Hox mutations are fascinating. Like magic, they can turn antennae into legs or create extra wings. What makes these genes so talented? How can they make such high-level decisions? Are there simple rules that can explain the effects they have on the development of individual cells? Do the genes act multiple times during the development of a tissue to micromanage individual cell fate decisions, or can they act relatively early to initiate developmental programs that run independently of their further input?