CGC Bibliography Paper 3056

Effects of anthelminthics with different modes of action on the behavior and development of Caenorhabditis elegans.

Bernt U, Junkersdorf B, Londershausen M, Harder A, Schierenberg E

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Citation:

Fundamental and Applied Nematology 21: 251-263 1998

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ARTICLE

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Abstract:

The anthelminthic effects of four substances known to have different modes of action - two well-established nematicides (ivermectin, mebendazole) and two compounds presently in development (annonin, PF 1022)-were evaluated from the results of in vitro and in vivo tests with four different parasitic nematodes. To determine to what extent the test results also apply to free-living nematodes, the effects of the same drugs on locomotion, reproduction, development, and cellular structures of the well-studied free-living species Caenorhabditis elegans were analysed in detail. The role of culture conditions, exposure time necessary for induction of defects, and reversibility of drug effects were also studied. Each of the tested substances induces a specific defect pattern. Our data indicate that it is necessary to combine results from different tests in order to obtain a comprehensive picture of the anthelminthic effects of a substance and hence of its potential suitability as a nematicide.